SIGNOR_ID COMPLEX_NAME MEMBERS COMPLEX_PORTAL_ID DESCRIPTION SIGNOR-C1 NFY P25208;P23511;Q13952 CPX-1956 SIGNOR-C10 SMAD4/JUN P05412;Q13485 SIGNOR-C100 ULK1/Atg13/Fip200 Q8TDY2;O75143;O75385 ULK1/Atg13/Fip200 SIGNOR-C101 TSC Q92574;P49815 CPX-6142 TSC1/TSC2 SIGNOR-C102 SUZ12/EZH2/YY1 SIGNOR-C77;P25490 SUZ12/EZH2/YY1 SIGNOR-C103 NLI/Lmx1.1/Isl1 P61371;Q8TE12;Q9GZU7 NLI/Lmx1.1/Isl1 SIGNOR-C104 RFX complex O14593;P48382;O00287 CPX-6461 RFX complex SIGNOR-C105 CoREST-HDAC complex Q92769;Q9UKL0;O75362;O60341;Q13547 CoREST-HDAC complex SIGNOR-C106 LMX1B/SFPQ/PSPC1 complex O60663;P23246;Q8WXF1 LMX1B/SFPQ/PSPC1 complex SIGNOR-C107 DNA-PK P12956;P78527;P13010 CPX-3403 Ku70/Ku80/DNA-PK SIGNOR-C108 NC2 complex Q01658;Q14919 NC2 complex SIGNOR-C109 ATG12/5/16L1 Q676U5;Q9H1Y0;O94817 CPX-200 ATG12/ATG5/ATG16L1 SIGNOR-C11 SMAD2/SMURF2 Q9HAU4;Q15796 SIGNOR-C110 GSK3B/Axin/APC P25054;P49841;O15169 GSK3B/Axin/APC SIGNOR-C111 REST-CoREST Q9UKL0;Q13127 REST-CoREST SIGNOR-C112 PARD6/SMURF1 Q9HCE7;Q9NPB6 PARD6/SMURF1 SIGNOR-C113 RAGAC Q7L523;Q9HB90 CPX-2542 RAGAC SIGNOR-C114 RAGAD Q9NQL2;Q7L523 CPX-2513 RAGAD SIGNOR-C115 RAGBC Q9HB90;Q5VZM2 CPX-2514 RAGBC SIGNOR-C116 RAGBD Q9NQL2;Q5VZM2 CPX-767 RAGBD SIGNOR-C117 AEP complex Q03111;P51825;Q9UHB7;SIGNOR-C238 AEP complex SIGNOR-C118 STAT1/STAT3 P40763;P42224 CPX-6041 STAT1/STAT3 SIGNOR-C119 Cullin4-RBX1-DDB1 Q13619;P62877;Q16531;Q96SW2 CPX-2759 SIGNOR-C12 SMAD7/HDAC1/E2F-1 O15105;Q13547;Q01094 SIGNOR-C120 JAK1/STAT1/STAT3 SIGNOR-C118;P23458 JAK1/STAT1/STAT3 SIGNOR-C121 PKCtheta/Nfix Q14938;Q04759 PKCtheta/Nfix SIGNOR-C122 Six1/Dach Q15475;Q9UI36 SIGNOR-C123 MTA1/DJ1 complex Q13330;Q99497 MTA1/DJ1 complex SIGNOR-C124 ISGF3 complex P42224;Q00978;P52630 CPX-6016 ISGF3 complex SIGNOR-C125 AHR-ARNT P27540;P35869 AHR-ARNT SIGNOR-C126 a7/b1 integrin Q13683;P05556 CPX-1804 alpha7 beta1 integrin SIGNOR-C127 MYOD/E12E47 P15172;P15923 MyoD homodimers or heterodimers of MyoD plus E12 or E47 serve as transcription factor complexes that bind to CANNTG consensus sites in the promoter regions of genes, performing major functions in specification and differentiation of skeletal muscle precursor cells SIGNOR-C128 MYOD/HEB P15172;Q99081 MYOD/HEB SIGNOR-C129 MYOD/E2-2 P15172;P15884 MYOD/E2-2 SIGNOR-C13 NfKb-p65/p50 P19838;Q04206 CPX-5828 SIGNOR-C130 Polycomb repressive complex 2 Q6ZN18;O75530;Q15910;Q09028;Q15022 Polycomb repressive complex 2 (PRC2) SIGNOR-C131 NAE Q8TBC4;Q13564 CPX-2587 Nedd8-activating enzyme SIGNOR-C132 PP2CA_R1A_R2A P67775;P30153;P63151 PP2Ca_R1A_Ba SIGNOR-C133 PP2Ca_R1A_Bd P30153;Q00005;P67775 PP2Ca_R1A_Bd SIGNOR-C134 PP2Ca_R1A_Bd P30153;Q14738;P67775 PP2Ca_R1A_Bd SIGNOR-C135 SCF-FBW7 Q969H0;Q13616;P63208 SCF-FBW7 SIGNOR-C136 SCF-SKP2 Q13616;Q13309;P63208 SCF-SKP2 SIGNOR-C137 GUCY1A2-B2 O75343;P33402 GUCY1A2-B2 SIGNOR-C138 GUCY1A2-B3 P33402;Q02153 CPX-2860 GUCY1A2-B3 SIGNOR-C139 GUCY1A3-B2 Q02108;O75343 GUCY1A3-B2 SIGNOR-C14 IKK-complex O14920;O15111;Q9Y6K9 CPX-3269 SIGNOR-C140 GUCY1A3-B3 Q02108;Q02153 CPX-928 GUCY1A3-B3 SIGNOR-C142 IFNGR2/INFGR1 P15260;P38484 IFNGR2/INFGR1 complex SIGNOR-C143 CyclinD1/CDK6 Q00534;P24385 CPX-2014 SIGNOR-C144 CDK5/CDK5R1 Q00535;Q15078 CPX-2201 SIGNOR-C146 ARP2/3 Q92747;O15144;O15145;P59998;O15511;P61158;P61160 CPX-2586 A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. SIGNOR-C147 MRE11/RAD50/NBS1 P49959;Q92878;O60934 CPX-4442 The mre11_rad50_nbs1 (mrn) complex is among the earliest respondents to dna double-strand break SIGNOR-C149 hb:hp P00738;SIGNOR-C209 The complex formation between Hp and Hb has been studied for decades and represents one of the strongest noncovalent interactions reported in plasma, with only some minor variations in binding strength of the Hp phenotypes (Hp1-1 > Hp2-1 > Hp2-2).After its release into plasma, Hb rapidly dissociates from the α2β2 tetrameric structure into αβ-dimers with the ability to bind Hp. The Hp region involved in binding these Hb (αβ)-units was recently shown by deletion analysis to include Hp1 β-chain residues 243 to 258.Hence, the Hp1-1 molecule is able to bind 2 Hb αβ-dimers (Figure 3), whereas the Hp2-1 and Hp2-2 may be able to bind several Hb αβ-dimers. Besides having a direct inhibitory effect on the toxic properties of Hb, as well as preventing peroxidative modification of Hb, Hp highly expedites Hb clearance, leading to production of anti-inflammatory metabolites. SIGNOR-C15 AMPK Q13131;O43741;Q9UGJ0;Q9UGI9;Q9Y478;P54646;P54619 CPX-5633 SIGNOR-C150 APC-c Q9NYG5;Q9UJX3;Q13042;Q9UM13;Q9UJX2;Q9UJX5;Q9BS18;Q9UJX4;Q8NHZ8;Q9H1A4;P30260;Q9UJX6 CPX-1860 Anaphase promoting complex SIGNOR-C151 Noncanonical PRC1 Q6W2J9;Q9BSM1;P63208;Q99496 inhibition of adipogenesis does not require the JmjC demethylase domain of FBXL10, but it does require the F-box and leucine-rich repeat domains, which we show recruit a noncanonical polycomb repressive complex 1 (PRC1) containing RING1B, SKP1, PCGF1, and BCOR. SIGNOR-C152 PAX2/TLE4 Q04727;Q02962 Recruitment of the groucho-related protein TLE4 may be involved in converting Pax2 into a transcriptional repressor SIGNOR-C153 TCR P01850;P01848;SIGNOR-C432 CPX-6581 The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes,[1] that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. SIGNOR-C154 AP1 P05412;P01100 CPX-486 The structure of AP-1 is a heterodimer composed of proteins belonging to the c-Fos, c-Jun families SIGNOR-C155 Calcineurin Q08209;P63098 Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase) SIGNOR-C156 PI3K P42336;P27986 CPX-2384 Class I PI3K are heterodimeric molecules composed of a regulatory and a catalytic subunit SIGNOR-C157 LE-TGN SNARE O60499;O14662;Q15836;Q96AJ9 Late endosomes- Trans Golgi Network soluble NSF attachment protein receptor (SNARE) complex SIGNOR-C158 SMN complex Q9H840;Q8TEQ6;Q8WXD5;O14893;P57678;Q16637;Q9UHI6 CPX-6031 Survival of motor neuron (SMN) complex SIGNOR-C159 A1/b1 integrin P05556;P56199 CPX-1798 SIGNOR-C16 CyclinE/CDK2 O96020;P24941 CPX-2016 SIGNOR-C160 A2/b1 integrin P05556;P17301 CPX-1801 SIGNOR-C161 A3/b1 integrin P05556;P26006 CPX-1797 SIGNOR-C162 A4/b1 integrin P05556;P13612 CPX-1802 SIGNOR-C163 A5/b1 integrin P08648;P05556 CPX-1794 SIGNOR-C164 A6/b1 integrin P05556;P23229 CPX-1803 SIGNOR-C165 A8/b1 integrin P05556;P53708 CPX-1815 SIGNOR-C166 A9/b1 integrin P05556;Q13797 CPX-1816 SIGNOR-C167 A10/b1 integrin P05556;O75578 CPX-1817 SIGNOR-C168 A11/b1 integrin Q9UKX5;P05556 CPX-1818 SIGNOR-C169 AL/b2 integrin P05107;P20701 CPX-1825 SIGNOR-C17 CyclinB/CDK1 P14635;P06493 CPX-2007 SIGNOR-C170 AM/b2 integrin P05107;P11215 CPX-1826 SIGNOR-C171 AX/b2 integrin P05107;P20702 CPX-1827 SIGNOR-C172 AD/b2 integrin Q13349;P05107 CPX-1828 SIGNOR-C173 AIIB/b3 integrin P08514;P05106 CPX-1799 SIGNOR-C174 A6/b4 integrin P23229;P16144 CPX-1822 SIGNOR-C175 Av/b1 integrin P06756;P05556 CPX-1819 SIGNOR-C176 Av/b2 integrin P06756;P05107 SIGNOR-C177 Av/b3 integrin P05106;P06756 CPX-1795 SIGNOR-C178 Av/b5 integrin P06756;P18084 CPX-1796 SIGNOR-C179 Av/b6 integrin P06756;P18564 CPX-1820 SIGNOR-C18 CyclinD/CDK4 P11802;P24385 CPX-2010 SIGNOR-C180 Laminin-9 Q16363;P55268;P11047 CPX-1778 SIGNOR-C181 Laminin-8 Q16363;P07942;P11047 CPX-1777 SIGNOR-C182 Laminin-10 O15230;P11047;P07942 CPX-1779 SIGNOR-C183 Laminin-1 P25391;P07942;P11047 CPX-1770 SIGNOR-C184 Laminin-5 Q13751;Q16787;Q13753 SIGNOR-C185 Av/b8 integrin P26012;P06756 CPX-1821 SIGNOR-C186 AE/b7 integrin P38570;P26010 CPX-1824 SIGNOR-C187 A4/b7 integrin P26010;P13612 CPX-1823 SIGNOR-C189 SETDB1/NLK/CHD7 Q15047;Q9P2D1;Q9UBE8 SIGNOR-C19 HMT P61964;O14686;Q9UBL3 SIGNOR-C190 PAS complex Q92562;Q08AM6;Q9Y2I7 Sac3 assembles with PIKfyve and ArPIKfyve in a stable ternary complex and controls PtdIns(3,5)P2 levels SIGNOR-C191 WRC complex Q92558;Q9Y2A7;Q7L576;Q8WUW1;Q8IZP0 WAVE proteins are constitutively associated with four additional proteins in cells: Sra1/Cyfip1, Nap1/Hem-2, Abi and HSPC300. The components of this ~400 kDa pentamer, termed the WAVE regulatory complex (WRC) have all been implicated in control of Arp2/3 complex-mediated actin assembly in a wide range of systems. SIGNOR-C192 GATOR1 Q12980;Q8WTW4;O75140 CPX-6226 Inhibition of GATOR1 subunits (DEPDC5, Nprl2, and Nprl3) makes mTORC1 signaling resistant to amino acid deprivation. SIGNOR-C193 GATOR2 Q96S15;Q6PJI9;P55735;Q96EE3;Q9NXC5 CPX-6227 Inhibition of GATOR2 subunits (Mios, WDR24, WDR59, Seh1L, and Sec13) suppresses mTORC1 signaling, and epistasis analysis shows that GATOR2 negatively regulates DEPDC5 SIGNOR-C195 CLOCK/BMAL1 O15516;O00327 CPX-3229 SIGNOR-C196 CLOCK/BMAL2 O15516;Q8WYA1 CPX-3230 SIGNOR-C197 CBFA2T3/ZNF651 O75081;Q9UFB7 Heterodimeric transcription factor SIGNOR-C198 SNAIL/RELA/PARP1 P09874;Q04206;O95863 The endogenous proteins PARP1, p65NF-κB and Snail1 form a ternary complex in the nuclei of cells that are actively expressing fibronectin SIGNOR-C199 FCER1G/FCER1G P30273 SIGNOR-C2 mTORC2 Q8TB45;P42345;P68104;Q9BVC4;P85299;Q6R327 mTORC2 SIGNOR-C200 FCER1 P12319;Q01362 SIGNOR-C202 GNB/GNG P62873;P59768 GNB1/GNG2 SIGNOR-C203 SMAD2/STAT3/EP300 Q15796;P40763;Q09472 SMAD2/STAT3/EP300 SIGNOR-C204 SMAD3/PIAS3 P84022;Q9Y6X2 SMAD3/PIAS3 SIGNOR-C205 SMAD5/SMAD4 Q13485;Q99717 SIGNOR-C206 SMAD8/SMAD4 Q13485;O15198 SIGNOR-C207 Neurofilament L/M P07197;P07196 Neurofilaments are obligate heteropolymers that are minimally comprised of the low molecular neurofilament protein L (NFL) plus the medium and/or high molecular weight proteins neurofilament protein M (NFM) and neurofilament protein H SIGNOR-C208 Neurofilament L/H P12036;P07196 Neurofilaments are obligate heteropolymers that are minimally comprised of the low molecular neurofilament protein L (NFL) plus the medium and/or high molecular weight proteins neurofilament protein M (NFM) and neurofilament protein H SIGNOR-C209 Hemoglobin P68871;P69905 CPX-2158 SIGNOR-C21 CDON/SPAG9 O60271;Q4KMG0 SIGNOR-C210 FN1/SDC4 P31431;P02751 FN1/SDC4 SIGNOR-C211 RUNX2/EP300 Q09472;Q13950 In osteoblastic cells expressing OC, p300 and RUNX2/Cbfa1 are components of the same nuclear protein complex SIGNOR-C212 CSF2RA/CSF2RB P15509;P32927 Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. SIGNOR-C214 Core Binding Factor complex Q01196;Q13951 The core binding factor (CBF) transcription complex, consisting of the interacting proteins RUNX1 and CBFβ, is essential for normal hematopoiesis SIGNOR-C215 SMAD1/5/8/SMAD4 Q13485;SIGNOR-PF35 COMPLEX FORMED BY SMAD1/5/8 FAMILY AND SMAD4 SIGNOR-C216 FZD7/SDC4 P31431;O75084 FZD7/SDC4 complex SIGNOR-C217 DGC Q16585;P56539;Q9Y4J8;Q9NSN8;P11532;Q16586;P29475;O60941;Q9NY99;Q13425;P24043;Q13326;Q14118;Q13884;Q13424;Q92629 The Dystrophin Glycoprotein Complex (DGC) is composed of dystrophin, an elongated cytoskeletal protein that links to cytoplasmic gamma-actin and the transmembrane components of the DGC. SIGNOR-C218 MAPK12/CARM1 Q86X55;P53778 P38gamma-CARM1 complex SIGNOR-C219 LPR5/6 O75581;O75197 Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) are co-receptors for Wnt ligands SIGNOR-C220 Caspase 1 complex P29466 CPX-952 Heterotetramer consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. SIGNOR-C221 Caspase 3 complex P42574 CPX-970 Tetramer composed by two p17 and two p12 Caspase-3 subunits. SIGNOR-C222 AIM2 inflammasome P29466;O14862;Q9ULZ3 CPX-4142 SIGNOR-C223 NLRC4 inflammasome Q9NPP4;Q9ULZ3;P29466;Q13075 CPX-4144 SIGNOR-C224 NLRP1 inflammasome Q9C000;Q9ULZ3;P29466 CPX-4082 SIGNOR-C225 NLRP3 inflammasome Q96P20;P29466;Q9ULZ3 CPX-4141 SIGNOR-C226 Pyrin inflammasome Q9ULZ3;O15553;P29466 CPX-4143 SIGNOR-C227 Caspase 2 complex P42575 CPX-969 Caspase-2 consists of anti-parallel arranged heterodimers of p12/p18 subunits. SIGNOR-C228 Caspase 6 complex P55212 CPX-971 Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. SIGNOR-C229 Caspase 9 complex P55211 CPX-991 Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. of Caspase-9. SIGNOR-C23 TAF3/TRF3 Q5VWG9;Q6SJ96 SIGNOR-C230 Apoptosome O14727;P55211;P99999 CPX-3762 SIGNOR-C231 Caspase 8 complex Q14790 CPX-975 Tetramer composed by Caspase-8 p18 and p10 subunits. SIGNOR-C232 Caspase 7 complex P55210 CPX-2862 Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit of Caspase-7. SIGNOR-C233 Ribonucleotide reductase P31350;P23921 CPX-2194 Ribonucleotide reductase (RR) is responsible for the de novo conversion of the ribonucleoside diphosphates to deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair.RR consists of two subunits, hRRM1 and hRRM2.(pmid:14583450) SIGNOR-C234 CyclinD3/CDK6 Q00534;P30281 CPX-2013 Cyclin-dependent protein kinase complex SIGNOR-C238 P-TEFb P50750;O60563 CPX-222 PMID: 20618343 The positive transcription elongation factor b (P-TEFb) composed of CDK9 and cyclin T1 stimulates gene expression by enhancing RNA polymerase II (RNA pol II) processivity. SIGNOR-C24 DCX DET1-COP1 P62877;Q16531;Q8NHY2;Q7L5Y6;Q13619 SIGNOR-C240 Spike protein-ACE2 P59594;Q9BYF1 CPX-5683 SIGNOR-C241 Vps34 Complex II Q9P2Y5;Q14457;Q8NEB9;Q99570 CPX-74 SIGNOR-C242 Vps34 Complex I Q99570;Q14457;Q8NEB9;Q6ZNE5 CPX-73 SIGNOR-C243 IFNAR P17181;P48551 SIGNOR-C244 STC2/HMOX1 P09601;O76061 Stanniocalcin 2, forms a complex with heme oxygenase 1 (stressosome), binds hemin and is a heat shock protein.|Taken together, our findings point to three novel functions of STC2, and suggest that STC2 interacts with HO1 to form a eukaryotic 'stressosome' involved in the degradation of heme. SIGNOR-C245 AP-2 complex Q96CW1;P53680;P63010;O94973 CPX-5150 Adaptor complex SIGNOR-C246 Early Endosome Q9H1K0;Q9UL25;Q9UL26;P20338;Q15075;CHEBI:17283;P20339;P61026;P61106 SIGNOR-C247 AP-3 complex Q9Y2T2;O14617;O00203;Q92572 CPX-5051 SIGNOR-C248 AP-1 complex P61966;Q10567;Q9BXS5;O43747 CPX-5047 SIGNOR-C249 AP-2/clathrin vescicle SIGNOR-C245;P09497;Q00610;P53675;P09496;CHEBI:18348 SIGNOR-C245 SIGNOR-C25 NKX3-1/SRF P11831;Q99801 SIGNOR-C250 AP-3/clathrin vescicle P53675;P09496;SIGNOR-C247;SIGNOR-C445;P09497;CHEBI:18348;Q00610 SIGNOR-C251 AP-1/clathrin vescicle P09496;Q00610;P09497;CHEBI:17526;SIGNOR-C248;P53675 SIGNOR-C252 BLOC-2 Q969F9;Q86YV9;Q9UPZ3 CPX-5044 SIGNOR-C253 BLOC-3 Q9NQG7;Q92902 CPX-5043 SIGNOR-C254 CoV2 Spike protein-ACE2 Q9BYF1;P0DTC2 SIGNOR-C255 Exosome_Complex Q96B26;Q9NQT5;Q13868;Q06265;Q9NQT4;Q8TF46;CHEBI:18420;Q01780;Q15024;Q5RKV6;Q9NPD3;Q9Y3B2 CPX-600 SIGNOR-C256 EIF4E2/GIGYF1 complex O75420;O60573 SIGNOR-C257 EIF4E2/GIGYF2 complex O60573;Q6Y7W6 SIGNOR-C258 WASH complex A8K0Z3;Q12768;Q2M389;Q9Y3C0;Q9Y4E1 CPX-1163 SIGNOR-C259 p62_complex P37198;Q7Z3B4;Q9BVL2 Thus, the p62-p58-p54 complex defines a group of proteins with strong protein-protein interactions that form a unit of pore structure essential for pore function. PMID:2050741 SIGNOR-C26 LAMTOR Q6IAA8;O43504;Q0VGL1;Q9UHA4;Q9Y2Q5 CPX-4741 SIGNOR-C260 IL17R complex Q96F46;Q8NAC3 SIGNOR-C261 DNA primase complex P49642;P49643 CPX-2087 SIGNOR-C262 DNA polymerase alpha:primase complex P09884;SIGNOR-C261;Q14181 CPX-2087 SIGNOR-C263 NPC P35658;Q96EE3;P12270;P49792;P49790;O15504;Q92621;P78406;P37198;Q7Z3B4;Q9BVL2;Q53GS7;Q96HA1;Q8TEM1;Q8NFH5;Q8N1F7;O75694;Q5SRE5;Q8NFH4;Q8WYP5;Q8NFH3;P55735;Q9NRG9;Q12769;Q9BW27;P57740;Q8WUM0;Q9BTX1;Q99567;Q9UKX7;P52948 CPX-873 SIGNOR-C264 ATP synthase P36542;O75964;P56385;P03928;P05496;P48047;P30049;P25705;P18859;Q9UII2;O75947;P24539;P06576 CPX-6151 Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L. SIGNOR-C265 Integrator complex Q68E01;Q9NVM9;Q8N201;Q96HW7;Q96SY0;Q9H0H0;Q6P9B9;Q9NVH2;Q96CB8;Q9NV88;Q75QN2;Q9NVR2;Q9UL03;Q5TA45 CPX-6441 SIGNOR-C266 28S mitochondrial small ribosomal subunit Q9NWT8;Q9Y676;Q9Y2Q9;Q9Y3D9;P82650;P82932;P82912;Q9Y2R9;P51398;Q96EY7;P82933;P82675;P82673;P82930;Q9Y291;Q92665;Q92552;Q9BYN8;P82663;Q96EL2;P82921;Q9Y399;Q9Y3D5;Q9Y2R5;Q9Y3D3;P82914;O60783;O15235;P82664;Q96BP2 CPX-5225 Component of the ribosome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Responsible for the catalytic activity of the ribosome, the peptidyltransferase activity required to catalyze peptide bond formation. The mitochondrial ribosome (mitoribosome) is responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. SIGNOR-C267 CoV2 spike protein-NRP1 O14786;P0DTC2 SIGNOR-C268 MCM P49736;Q14566;P25205;P33991;P33992;P33993 CPX-2940 The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication SIGNOR-C269 CHEVI complex Q9H267;Q9H9C1 CPX-6241 SIGNOR-C27 AMOT/MPP5/INADL/LIN7C Q8N3R9;Q8NI35;Q9NUP9 SIGNOR-C270 GPIb-IX-V complex P07359;P13224;P14770;P40197 CPX-114 SIGNOR-C271 WAVE complex Q8WUW1;Q7L576;Q8IZP0;Q9Y2A7;Q9Y6W5 SIGNOR-C272 STX11-SNAP23 SNARE complex O75558;O00161 SIGNOR-C273 STX11-VAMP8 SNARE complex Q15833;Q9BV40;O75558 SIGNOR-C274 KATP channel Q15842;O60706;Q09428;Q14654 SIGNOR-C275 VAPB-PTPIP51 complex Q96TC7;O95292 ER-mitochondrion tethering complex SIGNOR-C276 Mitochondrial Fe-S Cluster Assembly Complex Q16595;Q9H1K1;Q9Y697;Q9HD34 CPX-5641 Required for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins SIGNOR-C277 NADH-ubiquinone oxidoreductase-Mitochondrial respiratory chain complex I O95182;O43181;O75489;O95299;P19404;O15239;P49821;P03923;O75251;P03886;P03891;O43676;O43678;Q9P0J0;P03897;P03915;P03901;O96000;O43677;O75438;O95139;Q9Y6M9;P28331;O95169;Q16795;P03905;O75306;O75380;O00217;Q9NX14;P17568;Q86Y39;Q9UI09;P56181;O43920;P51970;O95168;Q16718;O95298;O95167;O95178;O43674;O14561;P56556 CPX-577 Catalyses the first step of electron transport by the oxidation of NADH, thus providing two electrons for the reduction of ubiquinone. SIGNOR-C278 Succinate dehydrogenase-Mitochondrial respiratory chain complex II P31040;P21912;Q99643;O14521 CPX-561 Accepts electrons from electron carriers reduced in glycolysis and the tricarboxylic acid cycle. SIGNOR-C279 CoQ-cytochrome c reductase-Mitochondrial respiratory chain complex III P31930;P08574;Q9UDW1;P00156;P07919;O14949;P47985;P14927;O14957;P22695 CPX-560 SIGNOR-C280 Cytochrome c oxidase-Mitochondrial respiratory chain complex IV P09669;P00395;P13073;P00414;P14854;P15954;P24311;P10606;P00403;P12074;P14406;P10176;O00483;P20674 CPX-6123 SIGNOR-C281 HAUS complex Q9BT25;Q96CS2;Q99871;O94927;Q7Z4H7;Q9H6D7;Q9NVX0;Q68CZ6 CPX-1847 SIGNOR-C282 g-TuRC complex Q96RT7;Q9UGJ1;Q96CW5;Q9BSJ2;Q96RT8 SIGNOR-C285 39S mitochondrial large ribosomal subunit Q9BRJ2;Q8N983;Q9BYD1;P49406;Q9BZE1;Q9BYD2;Q9NYK5;Q13405;Q9BYD3;Q96DV4;Q9P0J6;Q9NZE8;Q9BQ48;O75394;Q8TCC3;P09001;Q13084;Q9P0M9;Q96A35;Q16540;Q9NWU5;Q7Z2W9;Q9BYC9;Q5T653;Q9H0U6;Q9NX20;Q9P015;Q6P1L8;P52815;Q9Y3B7;Q7Z7H8;Q9BYD6;Q8TAE8;Q86TS9;Q9HD33;Q9BYC8;Q9BQC6;Q9NRX2;Q9NVS2;Q7Z7F7;Q6P161;Q4U2R6;Q8N5N7;Q14197;Q9NP92;Q96EL3;Q96GC5;Q9H2W6;Q9H9J2;Q9Y6G3;Q8IXM3;Q9NQ50 CPX-5226 SIGNOR-C286 40S cytosolic small ribosomal subunit P22090;P46781;P46782;P62241;P62854;P62753;P62273;P60866;P62857;P08865;P39019;P23396;P62701;P62263;P15880;P62081;P62841;P46783;P62861;P62280;P25398;P62277;P63220;P62244;P62249;P62847;P08708;P62269;P62266;P62851;P42677;Q71UM5;P62979;P61247;Q8TD47 CPX-5223 SIGNOR-C287 60S cytosolic large ribosomal subunit P62945;P62750;P46777;Q02878;Q07020;P40429;P05386;P05388;P32969;P62917;P62424;P18124;P36578;P63173;P61927;Q9Y3U8;P42766;P49207;P62910;P62888;P47914;P61353;P83731;P62829;P84098;Q02543;P62906;P62891;Q96EH5;P83881;Q969Q0;Q9UNX3;Q96L21;P62987;P18621;P46778;P27635;P50914;P30050;P62899;P35268;P61254;P61313;Q6P5R6;P46779;Q92901;P26373;P62913;P18077;P39023;P05387;P61513;P46776 CPX-5183 SIGNOR-C288 BBsome complex Q96RK4;Q8N3I7;Q8IWZ6;Q8NFJ9;Q8TAM2;Q9BXC9;Q3SYG4;A8MTZ0 CPX-1908 SIGNOR-C289 DPM complex Q9P2X0;O60762;O94777 CPX-6268 dolichyl beta-D-mannosyl phosphate synthase complex SIGNOR-C29 BMPR1A/1B/2 O00238;Q13873;P36894 SIGNOR-C290 Hair cells mechanotransduction channel Q92508;Q8TDI8;Q8TDI7;Q9H5I5 SIGNOR-C291 TIP-LINK complex Q13402;Q9H251;Q9Y6N9;Q495M9;Q96QU1 SIGNOR-C292 Caspase-2 PIDDosome P78560;Q9HB75;P42575 CPX-3905 SIGNOR-C293 Calprotectin complex P06702;P05109 CPX-37 S100A9-S100A8 complex SIGNOR-C294 SAE1/SAE2 complex Q9UBT2;Q9UBE0 CPX-2161 SUMO activating enzyme complex SIGNOR-C295 BRCC ubiquitin ligase complex P46736;SIGNOR-C297;Q9NXR7;P51587;Q06609 CPX-955 SIGNOR-C296 BRCA1-A complex SIGNOR-C297;Q9NXR7;Q6UWZ7;P46736;Q9NWV8;Q96RL1 CPX-4425 SIGNOR-C297 BRCA1-BARD1 complex P38398;Q99728 CPX-715 SIGNOR-C298 BRCA1-B complex Q9BX63;SIGNOR-C297;CHEBI:49883;Q92547 CPX-4426 SIGNOR-C299 BRCA1-C complex CHEBI:29105;CHEBI:29035;CHEBI:4705;SIGNOR-C147;Q99708;SIGNOR-C297 CPX-4441 SIGNOR-C3 mTORC1 Q9BVC4;Q8N122;P42345;Q96B36;Q8TB45 SIGNOR-C30 ACVR1/BMPR2 Q13873;Q04771 SIGNOR-C300 Fanconi anemia core complex O15360;O15287;Q9BTP7;Q0VG06;Q9HB96;Q8NB91;Q8IYD8;Q00597;Q9NW38;Q9NPI8 CPX-6263 SIGNOR-C301 D1-D2-G-X3 complex Q9BXW9;O15287;P51587;O43542 SIGNOR-C302 Fanconi anemia ID complex Q9NVI1;Q9BXW9 CPX-6264 SIGNOR-C303 LINC complex Q8WXH0;Q9UH99;Q8NF91;Q8TAQ9;Q8N6L0;Q8TC36;Q8N205;Q9NPE6;Q6ZMZ3;O94901 A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis. SIGNOR-C304 Cohesin complex O60216;Q8WVM7;SIGNOR-PF52;Q9UQE7;Q14683 CPX-5989 Cohesin is an evolutionarily conserved complex composed of four core proteins (SMC1A, SMC3, RAD21 and either STAG2 or STAG1) that form a ring-shaped structure able to encircle chromatin SIGNOR-C305 TTM complex Q8NHR7;Q8NA31;Q3KP22 Also known as TERB1-TERB2-MAJIN, tethers telomeres to the nuclear envelope. SIGNOR-C306 Shelterin complex P54274;SIGNOR-C64;Q9NYB0;Q9BSI4;Q15554 CPX-152 The Shelterin (Telosome) complex is a DNA-binding protein complex that associates with and protects the telomeres. SIGNOR-C307 26S Proteasome P28066;P25789;Q99460;P62195;P25787;P28070;Q99436;O00232;P17980;Q15008;O14818;Q13200;P49721;P60900;P28074;P20618;O43242;P60896;P25788;Q16186;O00487;P55036;P51665;O00231;P49720;P28072;P25786;P62333;P43686;P62191;P35998;Q9UNM6;P48556 CPX-5993 Multi-enzyme complex that functions as the primary degradation machinery for the selective turnover of surplus or damaged proteins within the cell. SIGNOR-C308 Complement C1q P02746;P02747;P02745 CPX-1919 SIGNOR-C309 Complement C1 complex SIGNOR-C308;P09871;P00736 CPX-1920 SIGNOR-C310 C3 convertase complex P06681;P0C0L5;P0C0L4 CPX-6156 Also known as C4b2a, it is formed by the complement cleavage products C4b and C2a. It cleaves C3 into C3a and C3b. SIGNOR-C311 Fibrinogen P02671;P02679;P02675 CPX-1922 SIGNOR-C312 C5 convertase complex P01024;SIGNOR-C310 CPX-6158 Also known as C4b2a3b, it is formed by the complement cleavage products C4b, C2a and C3b. It cleaves C5 into C5a and C5b. SIGNOR-C313 Membrane attack complex P07358;P02748;P13671;P07357;P01031;P10643;P07360 CPX-6159 Also known as MAC complex, it creates pores that disrupt the cell membrane of target cells, leading to cell lysis and death. SIGNOR-C314 C3 convertase complex (C3bBb) P00751;P01024 CPX-5601 Alternative complement pathway C3 convertase. SIGNOR-C315 C5 convertase complex (C3bBbC3b) P01024 CPX-5604 Alternative complement pathway C5 convertase. SIGNOR-C316 Thrombin-Thrombomodulin P00734;P07204 CPX-6223 SIGNOR-C317 Fibrin SIGNOR-C311 CPX-6225 Fibrin monomer SIGNOR-C318 Factor Va-Xa P12259;P00742 CPX-6221 SIGNOR-C319 Factor FVIIa:TF P08709;P13726 CPX-2808 SIGNOR-C32 RISC(DICER1/AGO2/TARBP2) Q9UKV8;Q9UPY3;Q15633 CPX-134 SIGNOR-C320 Factor VIIIa-IXa P00740;P00451 CPX-6204 Coagulation factor SIGNOR-C321 CENP-A nucleosome P06899;P49450;P62805;P04908 CPX-5647 SIGNOR-C322 Nucleosome_H2A.Z.1 variant P06899;P68431;P0C0S5;P62805 CPX-5670 SIGNOR-C323 Nucleosome_H2A.Z.2 variant Q71UI9;P68431;P62805;P06899 CPX-5671 SIGNOR-C324 Nucleosome_H3.1 variant P06899;SIGNOR-PF70;P62805;P68431;P04908 CPX-2556 SIGNOR-C325 Nucleosome_H3.1t variant Q16695;P06899;P62805;P04908 CPX-2564 SIGNOR-C326 GABA-A (a4-b2-d) receptor P47870;P48169;O14764 CPX-2953 SIGNOR-C327 GABA-A (a4-b3-d) receptor O14764;P48169;P28472 CPX-2954 SIGNOR-C328 GABA-A (a6-b2-d) receptor O14764;P47870;Q16445 CPX-2952 SIGNOR-C329 GABA-A (a6-b3-d) receptor Q16445;O14764;P28472 CPX-2951 SIGNOR-C33 CDX2/PAX6/P300 Q09472;Q99626;P26367 SIGNOR-C330 GABA-A (a1-b1-g2) receptor P18507;P18505;P14867 SIGNOR-C331 GABA-A (a2-b1-g2) receptor P18507;P18505;P47869 SIGNOR-C332 GABA-A (a3-b1-g2) receptor P18505;P34903;P18507 SIGNOR-C333 GABA-A (a4-b1-g2) receptor P18505;P48169;P18507 SIGNOR-C334 GABA-A (a6-b1-g2) receptor P18505;P18507;Q16445 SIGNOR-C335 GABA-A (a5-b1-g2) receptor P18507;P31644;P18505 SIGNOR-C336 GABA-B receptor Q9UBS5;O75899 CPX-2955 SIGNOR-C337 MBD2/NuRD complex Q92769;Q14839;Q86YP4;Q8WXI9;Q16576;Q13330;Q12873;Q9UBB5;Q09028;O94776;Q9BTC8;Q13547 CPX-880 SIGNOR-C338 MBD3/NuRD complex O94776;Q13547;Q14839;Q86YP4;Q8WXI9;Q92769;O95983;Q16576;Q13330;Q9BTC8;Q12873;Q09028 CPX-922 SIGNOR-C339 Nucleosome_H3.3 variant P04908;P06899;P84243;P62805 SIGNOR-C34 RNA helicases DDX5/DDX17 Q92841;P17844 SIGNOR-C340 CERF P51531;Q9BXF3 Biochemical isolation of CECR2 revealed the presence of this protein as a component of a novel heterodimeric complex termed CECR2-containing remodeling factor (CERF). CERF comprises CECR2 and the ATP-dependent chromatin remodeler SNF2L, a mammalian ISWI ortholog expressed predominantly in the central nervous system. SIGNOR-C341 Condensin I Q15021;Q9BPX3;Q15003;Q9NTJ3;O95347 CPX-979 SIGNOR-C342 Condensin II Q6IBW4;Q9NTJ3;O95347;Q86XI2;P42695 CPX-985 SIGNOR-C343 TFIID Q15543;Q12962;P21675;P20226;P49848;Q7Z7C8;Q15542;Q6P1X5;Q15545;Q5VWG9;Q16594;Q15544;O00268;Q16514 CPX-915 SIGNOR-C344 MSL acetyltransferase Q9H7Z6;Q68DK7;Q8N5Y2;Q9HCI7 CPX-815 Human histone acetyltransferase complex (hMSL) that contains homologs of the Drosophila dosage compensation proteins MOF, MSL1, MSL2, and MSL3. This complex shows strong specificity for histone H4 lysine 16 in chromatin in vitro, and RNA interference-mediated knockdown experiments reveal that it is responsible for the majority of H4 acetylation at lysine 16 in the cell. PMID: 16227571 SIGNOR-C345 SF3a Q15459;Q12874;Q15428 CPX-2565 SIGNOR-C346 SNARE_complex P60880;P63027;Q16623 SIGNOR-C347 NMDA receptor_2A Q05586;Q12879 CPX-2202 SIGNOR-C348 NMDA receptor_2B Q13224;Q05586 CPX-285 SIGNOR-C349 NMDA receptor_2C Q14957;Q05586 CPX-286 SIGNOR-C350 NMDA receptor_2D Q05586;O15399 CPX-289 SIGNOR-C351 Synaptonemal_complex Q9BXU0;Q15431;Q8IZU3;A1L190;Q8N0S2;Q9BX26;Q6PIF2 SIGNOR-C352 Set1-Ash2 HMT complex O15047;Q9UBL3;P61964 SIGNOR-C353 BHC complex Q9UKL0;Q96BD5;Q9P0W2;Q13547;Q92769;O60341 SIGNOR-C354 Lig4-Xrcc4 complex P49917;Q13426 CPX-618 SIGNOR-C355 RAD21L Cohesin complex Q9UQE7;Q14683;Q9UJ98;Q9H4I0 CPX-7441 SIGNOR-C356 Microprocessor complex Q9NRR4;Q8WYQ5 CPX-3080 Microprocessor recognizes pri-miRNA through the stem- and the stem-loop-ssRNA junction, and cleaves both the 5′ and 3′ flanking segments to generate pre-miRNA. SIGNOR-C357 RZZ complex P50748;O95229;O43264;Q9H900 CPX-6017 SIGNOR-C358 NRZ complex Q6NUQ1;O43264;A2RRP1 CPX-6201 Multisubunit tethering complex for retrograde trafficking of COPI vesicles from the Golgi to the endoplasmic reticulum. SIGNOR-C360 MECP2/SIN3A/HDAC complex Q96ST3;Q92769;P51608;Q13547 SIGNOR-C361 Ndc80 complex Q9HBM1;O14777;Q9BZD4;Q8NBT2 CPX-550 Component of the KMN network. SIGNOR-C362 MIS12 complex Q9H410;Q6P1K2;Q96IY1;Q9H081 CPX-5643 Component of the KMN network SIGNOR-C363 KNL1 complex Q8NG31;O95229 CPX-5644 Component of the KMN network SIGNOR-C364 SKA complex Q8WVK7;Q8IX90;Q96BD8 CPX-5642 The Ska complex is an essential mitotic component required for accurate cell division in human cells SIGNOR-C365 CCAN complex Q71F23;Q5EE01;Q9BS16;Q13352;Q96H22;A8MT69;Q03188;Q92674;Q9NSP4;Q9BU64;Q6IPU0;Q7L2Z9;Q8N2Z9;Q96BT3;Q8N0S6;Q9H3R5 CPX-5646 SIGNOR-C366 KMN network SIGNOR-C363;SIGNOR-C362;SIGNOR-C361 The 10-subunit KMN assembly (comprising KNL1, MIS12, and NDC80 complexes, designated KNL1C, MIS12C, and NDC80C) binds microtubules and regulates mitotic checkpoint function through NDC80C and KNL1C. SIGNOR-C367 Upf-EJC Q9HAU5;Q92900;Q9BZI7 SIGNOR-C368 SEC61 complex P61619;P60468;P60059;Q9H9S3 translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) SIGNOR-C369 Exon junction complex P61326;P38919;Q9Y5S9;O15234 CPX-1941 SIGNOR-C37 CyclinK/CDK12 O75909;Q9NYV4 CPX-241 SIGNOR-C370 COPII vesicle P53992;P55735;Q9NQW1;O95487;O95486;O94979;O94855;Q15437;Q15436;O15027 Coat protein complex (COP) II vesicles export newly synthesized secretory proteins from the endoplasmic reticulum (ER). SIGNOR-C371 Nucleosome SIGNOR-PF69;SIGNOR-PF70;P62805;SIGNOR-PF68 SIGNOR-C372 POMT Q9UKY4;Q9Y6A1 CPX-2659 Protein O-mannosyltransferase 1 (POMT1) and its homologue POMT2 are responsible for the catalysis of the first step in O-mannosyl glycan synthesis SIGNOR-C373 Rix1 complex Q5SY16;Q9NXF1;Q8IZL8;Q9H4L4;Q9BV38 SIGNOR-C374 SMC5/6 Q96MF7;Q9NXX6;Q8IY18;Q96SB8;Q8WV22;Q96MG7 CPX-6086 SIGNOR-C375 RF-C complex P35249;P35251;P35250;P40938;P40937 CPX-415 Replication factor C (RF-C) complex binds to DNA primers and loads PCNA onto DNA, thereby increasing the processivity of DNA polymerases. SIGNOR-C376 DNA polymerase delta Q9HCU8;Q15054;P49005;P28340 CPX-2097 Believed to be the major polymerase for the elongation of both leading and lagging strands of chromosomal DNA in eukaryotic cells. SIGNOR-C377 DNA polymerase epsilon Q07864;Q9NR33;Q9NRF9;P56282 CPX-2108 Complex that plays a role in the elongation of both leading and lagging strands of chromosomal DNA in eukaryotic cells SIGNOR-C378 DNA polymerase gamma P54098;Q9UHN1 CPX-2093 Human mitochondrial DNA polymerase (Pol gamma) is the sole replicase in mitochondria. SIGNOR-C379 ESCRT-III O43633;Q96CF2;Q9Y3E7;Q7LBR1;Q8WUX9;Q96FZ7;Q9BY43;Q9HD42;Q9H444;Q9NZZ3;Q9UQN3 CPX-329 SIGNOR-C38 CyclinK/CDK13 Q14004;O75909 CPX-359 SIGNOR-C380 IPP complex P48059;Q13418;P0CW20;P0CW19;Q7Z4I7;Q9NVD7 Integrin-linked kinase (ILK), and isoforms of particularly interesting Cys-His-rich protein (PINCH) and parvin form the IPP complex. In the cytoplasm, and this complex is recruited to focal adhesions. SIGNOR-C381 BLOC-1 Q96EV8;Q9UL45;Q9NUP1;P78537;Q6QNY1;Q8TDH9;O95295;Q6QNY0 CPX-1910 Lysosome-related organelles complex-1 (BLOC-1). SIGNOR-C382 MCC O43684;O60566;Q12834;Q13257 CPX-3946 Mitotic Checkpoint Complex SIGNOR-C383 Ankyrin complex P02730;Q08722;P11166;P02724;P16452;Q14773;P06028;Q02094;P18577;P16157 Junctional complex required to maintain red blood cell mechanical integrity and stability. SIGNOR-C384 Erythrocytic spectrin P02549;P11277 CPX-2499 Heterodimer of erythrocytic alpha and beta spectrins. SIGNOR-C385 Non-erythrocytic spectrin Q13813;SIGNOR-PF73 Heterodimer of non-erythrocytic alpha and beta spectrins. SIGNOR-C386 4.1 complex P11171;P35611;P35612;P02730;P27105;P11166;P04921 Junctional complex required to maintain red blood cell mechanical integrity and stability. SIGNOR-C387 CFII complex Q92989;O94913 Cleavage factor II (CF II) is a heterodimer of PCF11 and CLP1 catalyzing 3′ cleavage and polyadenylation of mammalian mRNA precursors. SIGNOR-C388 CFI complex O43809;Q8N684;Q16630 Cleavage factor I (CF I) complex, involved in one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. SIGNOR-C389 RNA Polymerase III Q9BUI4;O75575;O15160;Q9Y2Y1;P53803;Q9NW08;P0DPB6;P52434;O14802;Q9Y535;O15318;Q9H1D9;P62875;P61218;Q9NVU0;P05423;P19388 CPX-2393 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.It synthesizes small RNAs, such as snRNA and tRNAs. SIGNOR-C39 DDB2/DDB1 Q92466;Q16531 CPX-308 SIGNOR-C390 RNA Polymerase I Q9P1U0;P62875;P61218;P19388;O15160;P0DPB5;Q3B726;O15446;Q9H9Y6;Q9GZS1;O95602;P53803;P52434;P0DPB6 CPX-2386 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It synthesizes rRNAs. SIGNOR-C391 RNA Polymerase II P24928;Q6EEV4;P19388;P52435;P52434;P53803;P30876;P19387;O15514;P62487;P36954;P0CAP2;P61218;P62875;Q9H1A7;Q9GZM3 CPX-7481 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It synthesizes mRNAs. SIGNOR-C392 TFIIIC Q9UKN8;Q969F1;Q9Y5Q8;Q9Y5Q9;Q8WUA4;Q12789 CPX-2373 Required for RNA polymerase III-mediated transcription. SIGNOR-C393 TFIIIB P20226;A6H8Y1;Q9HAW0;Q92994 Required for RNA polymerase III-mediated transcription. SIGNOR-C394 TFIIF P13984;P35269 CPX-79 TFIIF is a general transcription initiation factor that binds to RNA polymerase II. SIGNOR-C395 TFIIA P52657;P52655 CPX-519 TFIIA is a general transcription initiation factor that binds to RNA polymerase II. SIGNOR-C396 IDH P51553;P50213;O43837 CPX-553 Tricarboxylic acid cycle enzyme which catalyzes the conversion of threo-Ds-isocitrate to alpha-ketoglutarate and carbon dioxide, important for regulatory control of mitochondrial energy metabolism. SIGNOR-C397 OGDC Q9ULD0;P09622;P36957;Q02218 Oxoglutarate dehydrogenase complex SIGNOR-C398 Succinyl-CoA ATP variant P53597;Q9P2R7 CPX-6176 Mitochondrial succinyl-CoA synthetase complex, ATP-specific variant SIGNOR-C399 Succinyl-CoA GTP variant P53597;Q96I99 CPX-6175 SIGNOR-C401 EIF3_complex O15372;Q7L2H7;Q9Y262;Q9UBQ5;O75822;O75821;O15371;Q99613;P55884;O00303;P60228;Q14152;Q13347 CPX-6036 SIGNOR-C402 PDH O00330;P09622;P11177;P08559;P29803;P10515 CPX-6233 SIGNOR-C403 EBV gH:gL:gp42 P03212;P03205;P03231 Infection of B lymphocytes by Epstein-Barr virus (EBV) requires attachment of virus via binding of viral glycoprotein gp350 to CD21 on the cell surface. Penetration of the cell membrane additionally involves a complex of three glycoproteins, gH, gL, and gp42. Glycoprotein gp42 binds to HLA-DR. PMID: 9151859 SIGNOR-C405 Core mediator complex O95402;Q9ULK4;Q9Y3C7;Q9P086;Q9BUE0;O75586;Q13503;Q9H944;Q9NWA0;Q9H204;Q96HR3;Q9NPJ6;O60244;Q15648;O75448;Q71SY5;Q9Y2X0;Q9NVC6;Q9BTT4;O43513;Q9NX70;Q96G25;Q96RN5;Q15528;Q6P2C8;A0JLT2 CPX-3227 SIGNOR-C406 CKM complex P49336;Q9UHV7;Q93074;P24863;Q71F56 CPX-3232 Also known as CDK8 module. SIGNOR-C407 ChAHP Q14839;P83916;Q9H2P0;Q13185 ChAHP, a gene-regulatory complex that consists of the chromatin remodeller CHD4, the DNA-binding factor ADNP, and the heterochromatin proteins HP1β and HP1γ. SIGNOR-C408 Polycomb repressive complex 1 P35226;Q8IXK0;P78364;Q99496;P35227;Q14781 Polycomb repressive complex 1 (PRC1) SIGNOR-C409 Sin3B_complex Q96QT6;O75182;Q9UBU8;Q13547 SIGNOR-C41 DICER1/hAgo2/PRKRA Q9UPY3;O75569;Q9UKV8 CPX-1072 SIGNOR-C410 Outer_mitochondrial_membrane CHEBI:28874;CHEBI:16038;CHEBI:64482 The outer lipid bilayer of the mitochondrial envelope. SIGNOR-C411 Inner_mitochondrial_membrane CHEBI:64482;CHEBI:16038;CHEBI:28494 The inner lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae GO:0005743. SIGNOR-C412 TSH P01222;P01215 CPX-6096 TSH is a heterodimer composed of common alpha subunit and unique beta subunit encoded by genes located on different chromosomes. SIGNOR-C413 NSL histone acetyltransferase Q9H7Z6;Q96EZ8;Q9P2N6;Q9H9L4;P61964;Q9BVI0;P51610;O15294;Q7Z3B3 CPX-809 A histone acetyltransferase complex that catalyzes the acetylation of histone H4 on lysines 5, 8, and 16 but not on lysine 12. SIGNOR-C414 PCC P05165;P05166 CPX-6169 Propionyl-CoA carboxylase (PCC) is a biotin-dependent mitochondrial enzyme that catalyzes the conversion of propionyl-CoA to D-methylmalonyl-CoA. SIGNOR-C415 NatA Q9BXJ9;P41227 CPX-6271 NatA N-alpha-acetyltransferase complex SIGNOR-C416 NatB P61599;Q14CX7 CPX-6270 NatB complex catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln SIGNOR-C417 NatC Q5VZE5;Q147X3;Q9BRA0 CPX-6275 N-terminal acetyltransferase C (NatC) complex catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. SIGNOR-C418 HIF-1 complex Q16665;P27540 CPX-7381 Most, if not all, oxygen-breathing species express the highly conserved transcriptional complex HIF-1, which is a heterodimer composed of an alpha and a beta subunit, the latter being a constitutively-expressed aryl hydrocarbon receptor nuclear translocator (ARNT). (Wikipedia) SIGNOR-C419 ORC Q13415;Q9Y5N6;Q13416;O43929;Q9UBD5;O43913 CPX-1880 Nuclear origin of replication recognition complex SIGNOR-C42 DNMT1/DNMT3A P26358;Q9Y6K1 SIGNOR-C420 CyclinA2/CDK1 P06493;P20248 CPX-2004 Cyclin-dependent protein kinase complex. SIGNOR-C421 TOM40 complex Q96B49;Q15388;Q9NS69;Q9P0U1;O94826;Q8N4H5;O96008 CPX-6121 Translocase in the outer mitochondrial membrane that mediates the import of precursor protein and mediates inset of some resident outer membrane proteins. SIGNOR-C422 SAM complex O75431;Q13505;Q9Y512 CPX-6133 Mitochondrial sorting and assembly machinery SIGNOR-C423 TIM23 complex Q9Y5T4;P60602;O43615;P38646;Q9HAV7;Q96DA6;Q99595;Q3ZCQ8;Q9BVV7;Q8TAA5;Q9Y3D7;O14925 CPX-6129 Mitochondrial inner membrane pre-sequence translocase complex SIGNOR-C424 TIM22 complex Q6PF06;Q9Y5J7;P62072;Q53H12;Q9BSF4;Q9Y584 CPX-6124 Mitochondrial inner membrane twin-pore carrier translocase complex SIGNOR-C425 Class I MHC P61769;SIGNOR-PF87 The human class I Major Histocompatibility Complex (MHC I, also named the Human Leukocyte Antigen, HLA) consists of heavy (H) and light (L) chains, with the L chain being an invariant protein partner called beta-2 microglobulin (beta2m). SIGNOR-C426 Class I MHC:Antigen CHEBI:166824;SIGNOR-C425 The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR). SIGNOR-C427 Ubiquitinated-Viral_Protein SIGNOR-PF88;SIGNOR-PF89 SIGNOR-C428 Class II MHC SIGNOR-PF90;SIGNOR-PF91 Class II molecules are heterodimers consisting in two homogenous peptides, an α and β chain, both of which are encoded in the MHC. SIGNOR-C429 Class II MHC:Antigen CHEBI:166824;CHEBI:53000;SIGNOR-C428 MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules that bind peptides that are derived from extracellular proteins. SIGNOR-C43 DNMT1/DNMT3B P26358;Q9UBC3 SIGNOR-C430 α-D-glucosyl-glycogenin SIGNOR-PF95;CHEBI:58885 SIGNOR-C431 BMAL1/NPAS2 Q99743;O15516 SIGNOR-C432 CD3 P07766;P09693;P04234;P20963 SIGNOR-C433 BCR-Mk P0DOX6;P40259;P11912;P0DOX7 SIGNOR-C434 BCR-Ml P11912;P0DOX6;P0DOX8;P40259 SIGNOR-C435 BCR-Dk P11912;P0DOX7;P0DOX3;P40259 SIGNOR-C436 BCR-Dl P40259;P11912;P0DOX8;P0DOX3 SIGNOR-C437 Glycine cleavage system P23434;P09622;P48728;P23378 The glycine cleavage system is a mitochondrial multienzyme system composed of four proteins termed P, H, T and L-protein, and catalyzes the reversible oxidation of glycine yielding carbon dioxide, ammonia, 5,10-methylenetetrahydrofolate (5,10-CH2-H4folate), and reduced pyridine nucleotide. SIGNOR-C439 CCR4-NOT complex Q92600;Q9ULM6;Q9UFF9;Q96LI5;Q9C0C2;O75175;A5YKK6;O95628;Q9H9A5;Q9NZN8;Q9UIV1;Q9UKZ1 CPX-707 In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules. SIGNOR-C44 eIF4F_complex P06730;Q04637;Q14240 CPX-5634 SIGNOR-C440 Cap-binding complex Q09161;P52298 CPX-1427 The largely nuclear cap-binding complex (CBC) binds to the 5′ caps of RNA polymerase II (RNAPII)-synthesized transcripts and serves as a dynamic interaction platform for a myriad of RNA processing factors that regulate gene expression. SIGNOR-C441 CSTF complex P33240;Q12996;Q05048 CPX-2701 Cleavage stimulation factor (CstF) is a heterotrimer necessary for the first step, endonucleolytic cleavage, and it plays an important role in determining the efficiency of polyadenylation. SIGNOR-C442 SF3b Q9Y3B4;O75533;Q13435;Q15393;Q15427;Q9BWJ5;Q7RTV0 CPX-2227 Pre-mRNA splicing complex. SIGNOR-C443 NF90-NF45 Q12905;Q12906 SIGNOR-C444 TREX complex Q13838;Q6I9Y2;Q86V81;Q13769;Q96J01;Q86W42;Q8NI27;Q96FV9 SIGNOR-C445 Neuronal AP-3 P59780;O14617;Q13367;P53677 CPX-5053 SIGNOR-C446 MLL3 complex Q8NEZ4;SIGNOR-C87 SIGNOR-C447 B-WICH complex O60264;O00159;O75533;CHEBI:18111;Q9NR30;Q9UIG0;Q03468;P35659;Q9BQG0 CPX-1099 SIGNOR-C448 HNuRF P28370;Q12830;Q16576;Q09028 CPX-688 SIGNOR-C449 WICH Q9UIG0;O60264 CPX-757 SIGNOR-C450 GLI1/GLI2 P08151;P10070 GLI1 and GLI2 were shown to co-immunoprecipitate in PANC1 pancreatic cancer cells and RMS13 rhabdomyosarcoma cells.|Chromatin immunoprecipitation showed that GLI1 and GLI2 occupied the same regions at the BCL2, MYCN and CCND1 promoters. Furthermore, depletion of GLI1 inhibited GLI2 occupancy at these promoters, suggesting that GLI1/GLI2 interaction is required for the recruitment of GLI2 to these sites. SIGNOR-C451 SOX17/POU5F1 Q9H6I2;Q01860 SOX17 partners with OCT4/POU5F1 and binds to a unique ‘compressed' Sox/Oct motif that earmarks endodermal genes SIGNOR-C452 Ternary_GTP_eIF2_tRNA_complex CHEBI:16635;CHEBI:15996;P41091;P05198;P20042 CPX-2716 In eukaryotes, translation initiation generally occurs by a cap-dependent scanning mechanism, wherein the small (40S) subunit of the ribosome recruits methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation factor 2 (eIF2) SIGNOR-C453 43S_pre_initiation_complex SIGNOR-C286;P55010;P41567;SIGNOR-C452;SIGNOR-C401 43S pre-initiation complex (43S PIC), which consists of the 40S ribosomal subunit, translation initiation factors eIF1, eIF1A, eIF3, eIF5, and a ternary complex (TC) composed of eIF2, GTP and Met-tRNAiMet. SIGNOR-C454 48S_initiation_complex P23588;CHEBI:33699;SIGNOR-C453;SIGNOR-C44 The 48S complex scans mRNA from 5′ to 3′ until it identifies an AUG start codon in an appropriate sequence context (Kozak consensus) SIGNOR-C455 80S_cytosolic_ribosome SIGNOR-C286;SIGNOR-C287;CHEBI:33699 Complete structure of the eukaryotic ribosome, made of the large (60S) and small (40S) ribosomal subunits that assemble over the mRNA. SIGNOR-C456 CAK complex P51946;P50613;P51948 CPX-578 CdK activating kinase (CAK) complex, which harbors the kinase activity of CDK7 as well as the Cyclin H and MAT1 subunits SIGNOR-C457 TFIIH P18074;SIGNOR-C456;Q13889;Q92759;Q6P1K8;Q6ZYL4;P32780;P19447;Q13888 CPX-2395 Transcription factor IIH (TFIIH) is a heterodecameric protein complex critical for transcription initiation by RNA polymerase II and nucleotide excision DNA repair. SIGNOR-C458 TFIIE P29084;P29083 CPX-2394 The heterodimer TFIIE (composed of the TFIIEA and TFIIEB subunits) seems to play a pivotal role in transcription by directly influencing the transition from initiation to elongation SIGNOR-C459 NuA4 complex Q9NPF5;Q9NV56;Q9HAF1;Q9H2F5;Q52LR7;Q15014;Q9Y265;Q9Y230;Q15906;Q96L91;Q05BQ5;Q92993;Q9Y4A5;Q9NXR8;Q9H0E9;O96019;P60709;O95619;Q9UBU8 CPX-978 SIGNOR-C460 EEF1B complex P29692;P26641;P24534 EEIF1A a guanine nucleotide exchange factor SIGNOR-C461 HIRA complex 1 Q9NPG3;P54198;Q9Y6J0 SIGNOR-C462 HIRA complex 2 Q6ZU65;P54198;Q9Y6J0 SIGNOR-C463 ETF CHEBI:456215;P38117;P13804;CHEBI:57692 CPX-2731 SIGNOR-C464 SL1 complex Q15572;Q9H5J8;Q53T94;Q15573;P20226 SL1/TIF-IB complex or RNA polymerase I core complex, binds rDNA promoters and plays a role in Pol I recruitment SIGNOR-C465 SAGA complex Q9NPA8;Q7Z7C8;Q15573;Q9Y6J9;Q16594;Q12962;O94864;O75529;Q86TJ2;Q96ES7;Q14CW9;Q8NEM7;Q92831;O15265;O75486;Q16514;Q9Y4A5;Q6P1X5;Q92830;Q96BN2;O75528;Q9UPT9 CPX-900 A transcriptional co-activator complex that preferably acetylates histone H3 and possibly H4. Involved in chromatine remodelling and Pol II genes transcriptional activation. SIGNOR-C466 Elongator complex Q8TE02;Q0PNE2;Q9H9T3;Q6IA86;Q96EB1;O95163 CPX-1949 SIGNOR-C467 GBAF O96019;Q92922;Q9NZM4;Q9BQE9;Q9H8M2;Q15532;Q4VC05;P60709;Q96GM5;P51531;Q8WUZ0 CPX-4084 SIGNOR-C468 RalGAP1 Q86X10;Q6GYQ0 SIGNOR-C469 RalGAP2 Q86X10;Q2PPJ7 SIGNOR-C47 ELF4/RUNX1 Q01196;Q99607 SIGNOR-C470 SWI/SNF ACTL6A-ARID1A-SMARCA2 variant Q6STE5;Q969G3;Q92925;Q12824;Q8TAQ2;O14497;O96019;P60709;Q96GM5;P51531;Q92922 CPX-1164 SIGNOR-C471 PAF1C Q92541;Q6P1J9;Q9GZS3;Q8WVC0;Q8N7H5;Q6PD62 CPX-2381 SIGNOR-C472 Multiaminoacyl-tRNA synthetase P07814;P54136;P47897;Q12904;O43324;Q13155;P56192;Q15046;P41252;Q9P2J5;P14868 CPX-2469 SIGNOR-C473 Phenylalanyl-tRNA synthetase Q9NSD9;Q9Y285 CPX-2208 SIGNOR-C474 MPO-ANCA P0DOX5 Anti-MPO447–459 antibodies SIGNOR-C475 Pr3-ANCA P0DOX5 Anti-PR3 antibodies SIGNOR-C476 SWI/SNF ACTL6B varian Q12824;Q8WUB8;Q96GM5;P60709;Q9NPI1;O94805;Q68CP9;Q86U86;P51532;Q92925;Q969G3;Q92922;Q8TAQ2 CPX-1196 SIGNOR-C477 Neural progenitor-specific SWI/SNF O96019;P60709;Q96GM5;P51531;Q8WUB8;Q8TAQ2;Q92922;Q6STE5;Q969G3;Q12824;O14497 CPX-1201 SIGNOR-C478 U4/U6.U5 snRNP complex O95777;P09012;P55769;Q9UK45;Q9BUQ8;Q9Y333;Q9Y4Z0;Q9BTD8;Q96DI7;Q8WVK2;Q53GS9;Q15029;P83876;P62316;P62314;P62312;P62310;P62306;P62308;O75643;Q8WWY3;P62318;P14678;P62304;O43172;Q6P2Q9;Q9Y4Y9;O94906;O43290 CPX-2391 Under splicing conditions, the U4/U6 and U5 snRNPs form a 25S U4/U6.U5 tri-snRNP, in which the U4 and U6 snRNAs are base-paired, forming a three-way junction. SIGNOR-C479 U2 snRNP complex P62318;Q15459;O75533;Q8TAD8;P14678;P62304;Q13435;Q15393;Q15427;Q9BWJ5;Q9Y3B4;Q7RTV0;Q12874;Q15428;Q9BRD0;P62306;P62308;P62314;P62316;O43719;P08579;P09661;Q7L014;Q9Y388 CPX-2539 The U2 small nuclear ribonucleoprotein (snRNP) is an essential component of the spliceosome, the cellular machine responsible for removing introns from precursor mRNAs (pre-mRNAs) in all eukaryotes. U2 recognises the branch site sequence in introns. SIGNOR-C48 ELL/ICE1 P55199;Q9Y2F5 SIGNOR-C480 U1 snRNP complex P62308;P09012;P09234;P62314;P62316;P08621;P62318;P14678;P62306;P62304 CPX-2392 The U1 small nuclear ribonucleoprotein (snRNP) is an essential component of the spliceosome, the cellular machine responsible for removing introns from precursor mRNAs (pre-mRNAs) in all eukaryotes. The U1 snRNP recognizes the donor site sequence of the intron. SIGNOR-C481 Muscle cell-specific SWI/SNF ARID1A variant P51531;Q92925;Q969G3;Q6STE5;Q92922;Q8TAQ2;O14497;Q92784;O96019;P60709;Q96GM5;Q12824 CPX-1194 SIGNOR-C482 Muscle cell-specific SWI/SNF ARID1B variant Q969G3;P51531;Q96GM5;P60709;O96019;Q92784;Q8NFD5;Q12824;Q92925;Q6STE5;Q92922;Q8TAQ2 CPX-1223 SIGNOR-C483 Muscle cell-specific SWI/SNF SMARCA4 variant Q969G3;Q8TAQ2;Q92922;Q6STE5;Q92925;Q96GM5;P60709;Q92784;O94805;O14497;P51532;Q12824 CPX-1226 SIGNOR-C484 Embryonic stem cell-specific SWI/SNF Q92922;O14497;Q8WUB8;Q8WUZ0;Q96GM5;P60709;O96019;Q4VC05;Q92785;P51532;Q12824;Q9BQE9;Q969G3 CPX-1195 SIGNOR-C485 Brain-specific SWI/SNF SMARCA2 variant O14497;Q8TAQ2;Q969G3;Q92925;Q12824;P51531;P60709;O94805 CPX-1203 SIGNOR-C486 Brain-specific SWI/SNF SMARCA4 variant P51532;Q12824;Q92925;Q969G3;Q8TAQ2;P60709;O94805;O14497 CPX-1219 SIGNOR-C487 COP9 signalosome variant 2 Q99627;Q92905;P61201;Q7L5N1;Q9H9Q2;Q9UNS2;Q9BT78;Q13098 CPX-1871 SIGNOR-C489 COP9 signalosome variant 1 Q9UBW8;Q13098;Q99627;Q9BT78;Q7L5N1;P61201;Q92905;Q9UNS2 CPX-1870 SIGNOR-C49 ELL/ICE2 Q659A1;P55199 SIGNOR-C491 Exocyst_EXOC6B variant Q96A65;Q9UPT5;Q9NV70;O60645;O00471;Q8IYI6;Q9Y2D4;Q96KP1 CPX-4944 SIGNOR-C492 Exocyst_EXOC6 variant Q8IYI6;Q96A65;Q9UPT5;Q9NV70;Q96KP1;O60645;O00471;Q8TAG9 CPX-4943 SIGNOR-C493 EEF1A:GTP:aa-tRNA CHEBI:15996;P68104;CHEBI:2651 SIGNOR-C494 Translation release factor ERF1-ERF3 P15170;P62495;CHEBI:15996 CPX-2721 SIGNOR-C495 Ub:E1 (UBA1 substrate) SIGNOR-PF89;P22314 SIGNOR-C496 Ub:E1 (UBA6 substrate) SIGNOR-PF89;A0AVT1 SIGNOR-C497 Ub:E2 SIGNOR-PF89;SIGNOR-PF105 SIGNOR-C498 INO80 complex Q9Y265;Q8NBZ0;Q9C086;Q9H981;Q9H9F9;Q6PI98;Q6P4R8;P0C1Z6;Q96EZ8;Q9Y230;Q9Y5K5;O96019;P25490;Q9ULG1;Q53TQ3 CPX-846 SIGNOR-C499 MCU_MICUB_variant Q9H4I9;Q9BPX6;Q9NWR8;Q8IYU8;Q8NE86 CPX-5966 SIGNOR-C5 SCF-betaTRCP P63208;Q13616;Q9Y297 SIGNOR-C50 ERCC4/ERCC1 Q92889;P07992 CPX-478 SIGNOR-C500 MCU_MICU1_variant Q9H4I9;Q8NE86;Q9BPX6 CPX-5963 SIGNOR-C501 MCU_MICU3_variant Q9H4I9;Q8NE86;Q86XE3;Q9BPX6 CPX-5965 SIGNOR-C502 MCU_MICU2_variant Q9BPX6;Q8IYU8;Q9H4I9;Q8NE86 CPX-5961 SIGNOR-C503 Scribble_complex_DLG2-LLGL2_variant Q6P1M3;Q15700;Q14160 CPX-6184 SIGNOR-C504 Scribble_complex_DLG3-LLGL2_variant Q92796;Q14160;Q6P1M3 CPX-6185 SIGNOR-C505 Scribble_complex_DLG4-LLGL2_variant P78352;Q14160;Q6P1M3 CPX-6186 SIGNOR-C506 Scribble_complex_DLG5-LLGL2_variant Q8TDM6;Q14160;Q6P1M3 CPX-6187 SIGNOR-C507 Scribble_complex_DLG3-LLGL1_variant Q14160;Q15334;Q92796 CPX-6190 SIGNOR-C508 Scribble_complex_DLG5-LLGL1_variant Q14160;Q8TDM6;Q15334 CPX-6188 SIGNOR-C509 Scribble_complex_DLG4-LLGL1_variant Q15334;P78352;Q14160 CPX-6189 SIGNOR-C51 EXT1/EXT2 Q93063;Q16394 SIGNOR-C510 Scribble_complex_DLG2-LLGL1_variant Q14160;Q15334;Q15700 CPX-6191 SIGNOR-C511 Scribble_complex_DLG1-LLGL1_variant Q15334;Q12959;Q14160 CPX-6192 SIGNOR-C513 Prefoldin co-chaperone O60925;P61758;Q9UHV9;O15212;Q9NQP4;Q99471 CPX-6149 SIGNOR-C514 URI1 prefoldin co-chaperone Q9UHV9;Q9UBK9;O94763;Q9NUG6;O15212 CPX-6144 SIGNOR-C515 R2TP core co-chaperone Q9Y230;Q9H6T3;Q9NWS0;Q9Y265 CPX-6143 SIGNOR-C516 PAQosome co-chaperone complex L0R819;P19388;SIGNOR-C514;SIGNOR-C515;Q96MX6 CPX-6145 SIGNOR-C517 R2SP co-chaperone Q07617;Q9Y265;Q9Y230;Q8WWB5 CPX-6150 SIGNOR-C518 Ub:HECT_E3 SIGNOR-PF104;SIGNOR-PF89 SIGNOR-C519 Ub:RING_E3 SIGNOR-PF89;SIGNOR-PF106 SIGNOR-C52 FGFR1OP/CEP350 Q5VT06;O95684 SIGNOR-C520 Ub:RBR_E3 SIGNOR-PF107;SIGNOR-PF89 SIGNOR-C521 NELF Q8WX92;Q8IXH7;Q9H3P2;P18615 CPX-6267 SIGNOR-C522 BAF250b E3 ligase Q15369;P62877;Q13617;Q8NFD5 SIGNOR-C523 KPC Q5XPI4;Q9BSL1 SIGNOR-C524 VCB-Cul2 Q15370;P40337;P62877;Q15369;Q13617 SIGNOR-C525 SCF-FBW2 P63208;Q13616;Q9UKT8 SIGNOR-C526 Cullin 3-RBX1-Skp1 P63208;Q13618;P62877 SIGNOR-C527 LUBAC Q9BYM8;Q96EP0 SIGNOR-C528 Cullin 7-RBX1-Skp1 P63208;P62877;Q14999 SIGNOR-C529 Cullin 1-RBX1-Skp1 P62877;P63208;Q13616 SIGNOR-C53 CPSF complex Q9P2I0;Q10570;Q6UN15;Q9UKF6;O95639 CPX-2698 SIGNOR-C530 EDVP Q16531;Q9Y4B6;O95071 SIGNOR-C531 Elongin E3-Cul-5 Q9UBF6;Q15369;Q15370;Q93034 SIGNOR-C532 Erlin O75477;O94905 SIGNOR-C533 SCF(TBL1) P25054;O60907;P63208;Q8IUQ4;Q9UHX1 SIGNOR-C534 PRP19-CDC5L O43660;P11142;Q9UMS4;Q99459;Q9P013;Q8WYA6;O75934 CPX-5824 SIGNOR-C535 OST-A complex P0C6T2;P04843;A0A024RAD5;Q9NRP0;P61803;P61165;P46977;P04844 CPX-5621 SIGNOR-C536 OST-B complex P0C6T2;Q14165;P39656;P61803;P04843;P04844;P61165;Q8TCJ2;Q9H0U3 CPX-5622 SIGNOR-C537 Skp1-Pam E3 O75592;P63208 SIGNOR-C538 MITRAC complex Q7Z7K0;Q9BVV7;Q96I36;Q9GZY4;Q9Y2R0 MITRAC is a cytochrome c oxidase assembly intermediate complex that regulates mitochondrial translation in human mitochondria SIGNOR-C539 TRiC P48643;P17987;P40227;Q99832;P50991;P49368;P78371;P50990 CPX-6030 SIGNOR-C54 KAT6A/KAT6B Q8WYB5;Q92794 SIGNOR-C540 CyclinY/CDK16 Q8ND76;Q00536 CPX-379 CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that forms an active complex with cyclin Y (CCNY). SIGNOR-C541 CyclinY/CDK14 Q8ND76;O94921 CPX-364 Cyclin-dependent protein kinase complex which acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase. SIGNOR-C542 CyclinD3/CDK11A P30281;Q9UQ88 Kinase-cyclin complex formed by Cyclin D3 and CDK11A SIGNOR-C543 CyclinD3/CDK11B P30281;P21127 Kinase-cyclin complex formed by CDK11B (p58) and Cyclin D3 SIGNOR-C544 CyclinC/CDK19 P24863;Q9BWU1 Cyclin-CDK complex formed by CDK19 and CyclinC. SIGNOR-C545 CyclinC/CDK3 P24863;Q00526 CPX-330 Cyclin-dependent protein kinase complex formed by CDK3 and Cyclin-C SIGNOR-C546 CyclinE1/CDK3 Q00526;P24864 Cyclin-CDK complex formed by Cyclin E1 and CDK3, it promotes G1 to S phase transition SIGNOR-C547 CyclinA2/CDK18 P20248;Q07002 SIGNOR-C548 Iws1:Spt6:CTD complex Q9BYW2;Q96ST2;Q7KZ85 SIGNOR-C549 HOPS tethering complex Q9P253;P49754;Q9H270;Q9H269;Q96JC1;Q96AX1 CPX-6212 SIGNOR-C55 KAT6A/PML Q92794;P29590 SIGNOR-C550 CORVET tethering complex Q9H270;Q96AX1;Q9H269;Q8N3P4;Q9P253;Q8WUH2 CPX-6213 SIGNOR-C551 STX17-VAMP8 SNARE complex Q9BV40;P56962;O95721 SIGNOR-C552 STK35/PDIK1L Q8TDR2;Q8N165 SIGNOR-C553 PAN2-PAN3 deadenylation complex Q58A45;Q504Q3 SIGNOR-C554 CPC Q9NQS7;Q53HL2;Q96GD4;O15392 CPX-116 SIGNOR-C555 CBM O95999;Q9BXL7;Q9UDY8 SIGNOR-C556 YAP1/TAZ P46937;Q9GZV5 Transcription coactivators YAP/TAZ SIGNOR-C557 Phagocyte NADPH oxidase complex P19878;P04839;P63000;P14598;Q15080 CPX-1017 SIGNOR-C559 RQC complex P55072;O60524;Q9BQ70;Q92890;Q8TAT6;O94822 CPX-2656 SIGNOR-C56 KCNJ5/KCNJ3 P48544;P48549 CPX-3278 SIGNOR-C560 V-ATPase P15313;Q99437;P38606;Q9Y5K8;Q16864;Q9Y487;Q6P5S7;Q15904;O75787;P27449;Q9UI12;Q96A05;O15342;Q8N8Y2;P21283;O95670;Q13488 CPX-6904 SIGNOR-C561 CASK-Mint1-Veli complex Q02410;Q9NUP9;O14936 SIGNOR-C562 CUL3-RBX1-KEAP1 P62877;Q14145;Q13618 SIGNOR-C563 Ferritin P02792;P02794 SIGNOR-C564 Trifunctional enzyme P55084;P40939 SIGNOR-C565 SNAPC O75971;Q92966;Q16533;Q13487;Q5SXM2 CPX-8637 SIGNOR-C566 Endoplasmic reticulum membrane complex- EMC9 variant Q8N766;Q15006;Q9Y3B6;Q9P0I2;Q9NPA0;Q9BV81;Q8N4V1;Q5UCC4;Q5J8M3 CPX-5881 SIGNOR-C567 Endoplasmic reticulum membrane complex, EMC8 variant Q9P0I2;Q9NPA0;Q9BV81;O43402;Q15006;Q5J8M3;Q5UCC4;Q8N4V1;Q8N766 CPX-5848 SIGNOR-C568 TRAPP III complex, TRAPPC2 variant Q9Y5R8;Q7Z392;O43617;O75865;P0DI81;Q8IUR0;Q8WVT3;Q9UL33;Q9Y296;Q9Y2L5 CPX-4750 SIGNOR-C569 TRAPP III complex, TRAPPC2B variant Q9Y296;Q9Y2L5;Q9Y5R8;Q9UL33;Q8WVT3;Q8IUR0;Q7Z392;P0DI82;O43617;O75865 CPX-6903 SIGNOR-C570 Ribonuclease MRP complex O75817;O75818;Q6NW34;O95059;O95707;P78345;P78346;Q32NC0;Q969H6;Q99575;Q9BUL9 CPX-2876 SIGNOR-C571 Nucleolar ribonuclease P complex Q99575;O95059;O95707;Q969H6;P78345;P78346;O75817;O75818;Q9H633;Q9BUL9 CPX-2877 SIGNOR-C572 SHU complex Q19AV6;Q6NVH7;Q9NTI5;Q14159 CPX-2186 SIGNOR-C573 Interleukin-23 receptor-ligand complex P42701;Q9NPF7;Q5VWK5;P29460 CPX-383 SIGNOR-C574 CatSpermasome complex Q2WGJ8;Q7RTX7;A8MZ26;E9PQX1;Q5SY80;Q6ZRH7;Q86XM0;Q86XQ3;Q8NEC5;Q96P56;Q9H7T0;Q9NTU4 CPX-9165 SIGNOR-C575 Nexin-dynein regulatory complex Q86XH1;Q5VUJ9;Q96DY2;Q96MC2;Q9H069;Q9H095;O95995;Q5JU00;Q8NEE6;Q8IY82;Q8IXS2 CPX-8086 SIGNOR-C576 COG tethering complex Q14746;P83436;Q9Y2V7;Q9UP83;Q9H9E3;Q96MW5;Q96JB2;Q8WTW3 CPX-6199 SIGNOR-C577 TRAP complex Q9UNL2;P43308;P51571;P43307 CPX-8024 SIGNOR-C578 BOS complex, NOMO3 variant P69849;Q9BVK8;Q969V3 CPX-8023 SIGNOR-C579 BOS complex, NOMO2 variant Q969V3;Q5JPE7;Q9BVK8 CPX-8022 SIGNOR-C58 MLH1/PMS1 P40692;P54277 SIGNOR-C580 BOS complex, NOMO1 variant Q969V3;Q15155;Q9BVK8 CPX-8021 SIGNOR-C581 Signal peptidase complex, SEC11C variant Q15005;P61009;Q9BY50;Q9Y6A9 CPX-7205 SIGNOR-C582 Signal peptidase complex, SEC11A variant P67812;Q9Y6A9;Q15005;P61009 CPX-2847 SIGNOR-C583 Nax cation channel complex SCN2B-SCN3B variant O60939;Q9NY72;Q01118 CPX-8691 SIGNOR-C584 Nax cation channel complex, SCN3B-SCN4B variant Q8IWT1;Q9NY72;Q01118 CPX-8692 SIGNOR-C585 Nax cation channel complex, SCN1B-SCN4B variant Q01118;Q07699;Q8IWT1 CPX-8693 SIGNOR-C586 Nax cation channel complex, SCN1B-SCN2B variant O60939;Q07699;Q01118 CPX-8694 SIGNOR-C587 UTP-A complex Q15061;Q9H8H0;Q9H583;Q969X6;Q8TED0;Q8IWA0 CPX-2450 SIGNOR-C588 UTP-B complex Q8NI36;Q9NYH9;Q9UNX4;Q9Y5J1;Q12788;Q15269 CPX-2688 SIGNOR-C589 U3 snoRNP Q9Y2X3;P55769;P22087;O00567 SIGNOR-C59 MLH1/PMS2 P40692;P54278 SIGNOR-C590 AP-4 Adaptor complex Q9Y6B7;Q9Y587;Q9UPM8;O00189 CPX-5151 SIGNOR-C591 CoQ biosynthetic complex O75208;Q9Y2Z9;Q9NZJ6;Q99807;Q5HYK3;Q9Y3A0 CPX-3642 SIGNOR-C592 AP-5 Adaptor complex Q2VPB7;Q9H0R1;Q9NUS5;O43299 CPX-5181 SIGNOR-C593 Neuronal nicotinic acetylcholine receptor complex, 3xalpha4-2xbeta2 P17787;P43681 SIGNOR-C594 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2 P30532;P17787;P32297 SIGNOR-C595 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta4 P32297;P30532;P30926 SIGNOR-C596 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4 P30926;P32297;Q15825 SIGNOR-C597 Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2 P43681;P17787;P30532 SIGNOR-C598 Neuronal nicotinic acetylcholine receptor complex, alpha7-beta2 P17787;P36544 SIGNOR-C6 CBP/p300 Q09472;Q92793 SIGNOR-C60 MSH2/MSH6 P43246;P52701 CPX-80 SIGNOR-C600 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon P02708;Q04844;Q07001;P11230 SIGNOR-C601 RNase H2 complex Q8TDP1;Q5TBB1;O75792 CPX-745 SIGNOR-C602 MTERF4-NSUN4 mitochondiral ribosomal assembly complex Q96CB9;Q7Z6M4 CPX-885 SIGNOR-C603 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma P02708;P11230;Q07001;P07510 CPX-2179 SIGNOR-C604 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3 Q05901;P32297;P17787;Q15825 CPX-2192 SIGNOR-C605 NEXT complex, TENT4B-ZCCHC7 variant Q8N3Z6;P42285;Q8NDF8 SIGNOR-C606 NEXT complex, TENT4A-ZCCHC7 variant Q5XG87;Q8N3Z6;P42285 CPX-2749 SIGNOR-C607 ESCRT-I complex, VPS37A-UBAP1 variant Q8NEZ2;Q99816;Q9NZ09;Q9UK41 CPX-7181 SIGNOR-C608 ESCRT-II complex Q86VN1;Q96H20;Q9BRG1 CPX-2506 SIGNOR-C609 ESCRT-0 complex O14964;Q92783 SIGNOR-C61 MSN/PDZD8 Q8NEN9;P26038 SIGNOR-C610 NXF2-NXT1 mRNA nuclear export factor complex Q9GZY0;Q9UKK6 CPX-925 SIGNOR-C611 C-to-U editosome complex Q99729;O60506;P41238;Q9NQ94 CPX-1097 SIGNOR-C612 CPLANE complex Q9ULD6;Q9BT04;O95876 CPX-5001 SIGNOR-C613 ITF complex Q96FT9;Q9P2L0;Q9HBG6;Q7Z4L5;Q8NEZ3;Q96RY7 CPX-5021 SIGNOR-C614 Mitochondrial pyruvate carrier complex O95563;Q9Y5U8 CPX-6154 SIGNOR-C615 NXF2-NXT2 mRNA nuclear export factor complex Q9NPJ8;Q9GZY0 SIGNOR-C616 NXF5-NXT1 mRNA nuclear export factor complex Q9H1B4;Q9UKK6 CPX-2433 SIGNOR-C618 NXF3-NXT1 mRNA nuclear export factor complex Q9UKK6;Q9H4D5 SIGNOR-C619 NXF5-NXT2 mRNA nuclear export factor complex Q9NPJ8;Q9H1B4 CPX-2549 SIGNOR-C62 NONO/SFPQ Q15233;P23246 SIGNOR-C620 NXF3-NXT2 mRNA nuclear export factor complex Q9NPJ8;Q9H4D5 SIGNOR-C621 Tubulin polyglutamylase complex O95922;Q68CL5;Q6ZTW0;Q8IUZ0;Q9BSH3 SIGNOR-C622 USH2 complex O75445;Q8WXG9;Q9H5P4;Q9P202 CPX-2821 SIGNOR-C623 TDRD3-TOP3B type IA topoisomerase complex Q9H7E2;O95985 SIGNOR-C624 KICSTOR complex Q9Y664;Q969R8;Q5T011;Q96MD2 SIGNOR-C625 GET complex O43681;O00258;P49069 SIGNOR-C626 SPATA5-SPATA5L1 ATPase complex Q8NB90;Q9BVQ7;Q9NX04;Q9BW66 SIGNOR-C627 CST complex Q86WV5;Q9H668;Q2NKJ3 SIGNOR-C628 HUSH epigenetic repressor complex Q99549;Q9UK61;Q8NEY8 SIGNOR-C629 Lactose synthase complex P15291;P00709 SIGNOR-C630 CIAO2B cytosolic iron-sulfur protein assembly complex Q9Y3D0;Q96T76;O76071;Q9H6Q4 SIGNOR-C631 CIAO1-CIAO2A-CIAO3 cytosolic iron-sulfur protein assembly complex Q9H6Q4;O76071;Q9H5X1 SIGNOR-C632 CENP-A recruiting complex O43482;Q6P0N0;Q9NYP9 SIGNOR-C633 MON1-CCZ1 guanyl-nucleotide exchange factor complex, MON1B variant P86791;Q7L1V2;Q96DM3 SIGNOR-C634 MON1-CCZ1 guanyl-nucleotide exchange factor complex, MON1A variant Q96DM3;Q86VX9;P86791 SIGNOR-C635 MON1-CCZ1B guanyl-nucleotide exchange factor complex, MON1A variant Q96DM3;P86790;Q86VX9 SIGNOR-C636 MON1-CCZ1B guanyl-nucleotide exchange factor complex, MON1B variant P86790;Q7L1V2;Q96DM3 SIGNOR-C637 Mitochondrial BOLA1-GLRX5 iron-sulfur cluster assembly complex Q9Y3E2;Q86SX6 SIGNOR-C638 Mitochondrial BOLA3-GLRX5 iron-sulfur cluster assembly complex Q86SX6;Q53S33 SIGNOR-C639 ISCA2-IBA57 mitochondrial iron-sulfur protein assembly complex Q86U28;Q5T440 SIGNOR-C64 POT1/ACD Q9NUX5;Q96AP0 SIGNOR-C640 NUBP1-NUBP2 iron-sulfur cluster assembly scaffold complex Q9Y5Y2;P53384 SIGNOR-C641 ISCA1-ISCA2 mitochondrial iron-sulfur protein assembly complex Q9BUE6;Q86U28 SIGNOR-C642 BOLA2-GLRX3 iron-sulfur cluster assembly complex O76003;Q9H3K6 SIGNOR-C643 Vault ribonucleoprotein complex Q9UKK3;Q14764;Q99973 SIGNOR-C644 RAVE complex, DMXL1 variant Q9Y485;Q9Y4E6;Q9GZN7 SIGNOR-C645 Mitochondrial pyruvate carrier complex, testis variant P0DKB6;O95563 SIGNOR-C647 PAT intramembrane chaperone complex Q9Y284;Q96A33 CPX-7020 SIGNOR-C648 Mitochondrial glutamyl-tRNA(Gln) amidotransferase complex Q9H0R6;O75879;O43716 SIGNOR-C649 Ficolin lectin-protease complex P48740;O00602 SIGNOR-C65 RAD51B/RAD51C O15315;O43502 SIGNOR-C650 Fukutin-FKRP-TMEM5 multienzyme complex Q9H9S5;O75072;Q9Y2B1 SIGNOR-C651 ATP9A-DOP1B-MON2, golgi transporter complex Q9Y3R5;Q7Z3U7;O75110 SIGNOR-C652 Interleukin-37 receptor-ligand complex Q6IA17;Q13478 SIGNOR-C654 Ribosome-associated complex Q99543;Q0VDF9 SIGNOR-C655 CASTOR1-CASTOR2 arginine binding complex A6NHX0;Q8WTX7 SIGNOR-C656 CASTOR1-GATOR2 arginine binding complex Q9NXC5;Q8WTX7 SIGNOR-C657 TRMT11-TRM112 methyltransferase complex Q9UI30;Q7Z4G4 CPX-2848 SIGNOR-C658 METTL5-TRM112 methyltransferase complex Q9UI30;Q9NRN9 CPX-2850 SIGNOR-C659 THUMPD2-TRM112 methyltransferase complex Q9BTF0;Q9UI30 CPX-2852 SIGNOR-C660 ALKBH8-TRM112 methyltransferase complex Q9UI30;Q96BT7 CPX-2861 SIGNOR-C661 N6AMT1-TRM112 methyltransferase complex Q9Y5N5;Q9UI30 CPX-2866 SIGNOR-C662 BUD23-TRM112 methyltransferase complex Q9UI30;O43709 SIGNOR-C663 THUMPD3-TRM112 methyltransferase complex Q9UI30;Q9BV44 SIGNOR-C664 Adrenomedullin receptor AM1 complex O60895;Q16602 SIGNOR-C665 Adrenomedullin receptor AM2 complex O60896;Q16602 SIGNOR-C666 Amylin receptor 1 complex O60894;P30988 SIGNOR-C667 Amylin receptor 2 complex P30988;O60895 SIGNOR-C668 Amylin receptor 3 complex P30988;O60896 SIGNOR-C67 RBM15/NXF1 Q96T37;Q9UBU9 SIGNOR-C68 REL/RELA Q04864;Q04206 CPX-5834 SIGNOR-C7 P300/PCAF Q92831;Q92793;Q09472 SIGNOR-C71 SEPT6/SEPT2 Q15019;Q14141 SIGNOR-C72 SEPT6/SEPT7 Q16181;Q14141 SIGNOR-C73 SOX2/POU5F1 Q01860;P48431 SIGNOR-C74 SP1/STAT3 P40763;P08047 SIGNOR-C75 SS18/MLLT10 P55197;Q15532 SIGNOR-C76 SUZ12/EED O75530;Q15022 SIGNOR-C77 SUZ12/EZH2 Q15022;Q15910 SIGNOR-C78 U2AF1/U2AF2 P26368;Q01081 CPX-1921 SIGNOR-C8 SMAD2/SMAD4 Q13485;Q15796 CPX-3208 SIGNOR-C80 ZBTB16/ZBTB32 Q9Y2Y4;Q05516 SIGNOR-C81 ZRSR2/U2AF2 Q15696;P26368 SIGNOR-C83 CyclinA2/CDK2 P24941;P20248 CPX-2006 SIGNOR-C84 NR3C1/STAT5A P04150;P42229 SIGNOR-C85 SMAD1/4 Q15797;Q13485 CPX-54 SIGNOR-C86 SMAD3/JUN P05412;P84022 SIGNOR-C87 MLL/SET subcomplex Q9C005;Q9UPS6;Q15291;SIGNOR-C352 SIGNOR-C88 MLL2 complex SIGNOR-C87;O14686 SIGNOR-C89 MLL1 complex Q03164;SIGNOR-C87 SIGNOR-C9 SMAD3/SMAD4 P84022;Q13485 CPX-3252 SMAD3/SMAD4 SIGNOR-C90 PAX7/MLL1 complex SIGNOR-C89;P23759 SIGNOR-C91 PAX7/MLL2 complex SIGNOR-C88;P23759 SIGNOR-C92 SWI/SNF complex Q92922;P51532;Q12824;Q68CP9;Q8NFD5;O96019;O14497;Q8TAQ2;Q96GM5;Q969G3 SIGNOR-C93 MYOD1/SWI/SNF complex P15172;SIGNOR-C92;P40424 SIGNOR-C94 Myog/SWI/SNF complex Q14814;P15173;SIGNOR-C92 SIGNOR-C95 CDON/BOC/PTCH1 Q13635;Q4KMG0;Q9BWV1 CDON/BOC/PTCH1 SIGNOR-C97 RBPJ/NOTCH Q06330;SIGNOR-PF30;P46531 RBPJ/NOTCH SIGNOR-C98 gamma-secretase Q9NZ42;Q92542;Q96BI3;P49768 CPX-2176 gamma-secretase